Tue 04/Aug/2009

   Tue 04/Aug/2009

   DNA topoisomerase I-related function

   ATF2 is a nuclear protein detected abundantly in the brain. ATF2 also known as Cyclic AMP-dependent transcription factor ATF-2 is a transcriptional activator that binds DNA as a dimer and can form a homodimer in the absence of DNA. It binds through its N-terminal region to UTF1 which acts as a co activator of ATF2 transcriptional activity. ATF2 belonging to the bZIP family and ATF subfamily has a bZIP domain and a C2H2-type zinc finger. This transcriptional activator binds to the cAMP-responsive element (CRE) which is a consensus sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.
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